Sirna Library Screening

To better understand this complexity researchers are moving toward large screening projects to identify candidate genes involved in their biological question of interest.

Sirna library screening.

Sirna libraries composed of large numbers of sirnas have been developed and are used to identify sets of genes functionally involved in a particular biological process or disease. Adapted from hu et al. The sirna library brings a revolution in the efficiency of functional genomics research. A breast cancer cell line was transfected with a sirna library that targeted a variety of specific kinases.

Silencer sirna is a great choice for economical screening of pre defined gene families and popular pathways like kinases cell surface receptors and dna damage response. Genome wide sirna and microrna libraries. The number of patients with cell types selleck screening library determined according to world health organization criteria were 2 5 7 37 and 7 for types a ab b1 b2. In the pursuit of gene functionality rnai library screening has become a crucial research tool used to study gene function and comprehensive signaling pathways.

Cancer research 2012 14 r22. Screening often lies at the beginning of most discovery research. Take advantage of predefined gene families including druggable genes or whole genome. Sirna library minimize time cost of screening using highly functional sirna.

Skip to primary content. Prepare sirna liposome complexes in the wells of 96 well plates. Rnai screening has allowed researchers to study the functionality of genes in a cell both individually and in. Fast and easy online configuration and ordering of plated sirna microrna reagents.

The silencer select human apoptosis sirna library provides investigators with a focused sirna screening platform targeting the most up to date apoptosis gene targets thus enabling a detailed analysis of the apoptotic signaling pathway the silencer select human apoptosis sirna library contains three unique non overlapping sirnas per target for 924 genes. Sirna library provides a new and efficient way that bring about many original breakthroughs in biology especially for the discovery of new targets combined with. Library screening using genome wide sirnas as well as micrornas allows a researcher to analyze an entire signaling pathway of one or tens of thousands of genes. Learn more and view all available silencer sirna libraries.

Freedom with custom library design. Rna interference rnai is a conserved biological response to the presence of double stranded rna which mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids and regulates the expression of protein coding genes. Sirna library screening protocol.